Distribution of urinary hippuric acid concentrations by ALDH2 genotype.
نویسندگان
چکیده
منابع مشابه
Occupational and Environmental Medicine 1994;51:817-821 Distribution of urinary hippuric acid concentrations
Objectives-To clarify the relation between the genetic polymorphism of ALDH2 (low Km aldehyde dehydrogenase) and toluene metabolism. Methods-The study subjects were 253 toluene workers (192 men and 61 women with an age range of 18-66). The genotypes ofALDH2 were classified by artificial restriction fragment length polymorphism into the homozygous genotype of normal ALDH2 (NN), the homozygous ge...
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The biological monitoring for exposure to toluene is based on the measurement of urinary hippuric acid concentration (HA-U). In occupational health, workers exposed to toluene are examined for HA-U, because collection of urine samples is easy. The HA-U of some designers in a great household electrical products corporation who did not use toluene occupationally showed relatively high values. Fro...
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ABSTRACr It is not known whether urinary excretion of hippuric acid (HA) or orthocresol (0-Cr) is to be preferred for the biological monitoring of workers with occupational exposure to toluene. To study this, 42 printing trade workers with more than 10 years' exposure to a mixture of organic solvents including toluene (0-20 ppm) and 43 control subjects matched by age, smoking habits, and living...
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Background: Toluene is a harmful substance still being used as a solvent and catalyst in many industries that can increase the level of urinary hippuric acid (UHA). This study was designed to examine the level of toluene and UHA among workers of industrial site in seven companies in Sidoarjo, Indonesia and to analyze the risk factors for abnormal UHA. Methods: This study was an analytical cross...
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Aim of this study was to evaluate the biotransformation of simple phenols after ingestion of edible fruits and mixed food. It was analyzed hippuric acid in urine as biomarker of conjugation in the liver cells of glycine with aromatic phenolic acids such benzoic and salicylic acid from ingested food. Measurement of hippuric acid in urine samples of 10 healthy individuals: 5 female and 5 male wit...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1994
ISSN: 1351-0711
DOI: 10.1136/oem.51.12.817